β作動薬の結晶性で鏡像異性的に純粋な塩の形態及び薬剤としてのその使用

Abstract

Crystalline hydrochloride salt of (5-{(R)-2-[3-(4,4-diethyl-2-oxo-4H- benzo[d][1,3]oxazin-1-yl)-1,1-dimethylpropylamino]-1-hydroxy-ethyl}-2 -hydroxyphenyl)-methane sulfonamide (I), is new. Independent claims are included for: (1) a medicament combination comprising (I) and further active agent of one or more other compounds, which are anticholinergics, corticosteroids, phosphodiesterase 4-inhibitors, leukotriene D4 antagonists, epidermal growth factor receptor inhibitors, dopamine-agonists, H1-antihistamines and/or phosphatidylinositol 3-kinase inhibitors; and (2) preparing an inhalation solution comprising dissolving the active agent of (I). - ACTIVITY : Respiratory-Gen.; CNS-Gen.; Antiinflammatory; Antiasthmatic; Cytostatic; Antimicrobial; Virucide; Antibacterial; Fungicide; Protozoacide; Anthelmintic; Dermatological; Immunosuppressive. - MECHANISM OF ACTION : None given.
本発明は、N-(5-{2-[3-(4,4-ジエチル-2-オキソ-4H-ベンゾ[d][1,3]オキサジン-1-イル)-1,1-ジメチル-プロピルアミノ]-1-ヒドロキシ-エチル}-2-ヒドロキシ-フェニル)-メタンスルホンアミド、好ましくはN-(5-{(R)-2-[3-(4,4-ジエチル-2-オキソ-4H-ベンゾ[d][1,3]オキサジン-1-イル)-1,1-ジメチル-プロピルアミノ]-1-ヒドロキシ-エチル}-2-ヒドロキシ-フェニル)-メタンスルホンアミドの結晶性で、鏡像異性的に純粋な塩酸塩、及び呼吸器系疾病の治療における、単独または少なくとも1以上の他の活性成分と組み合わせた、長期にわたるβ模倣剤としてのその作用に関する。

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